Speak to Tristan at the hub after the main mission.
Mission and approach
Speak to Tristan at the hub after the main mission.
Encounter walkthrough
After the fight, loot the chest on the left and enter the right door.

Drop to the boss room on the left. The iron gate ahead reconnects to a Nexus if you need to recover.

The boss reuses an earlier enemy's attacks. Apply the strategy for that encounter.

The cinematic confirms that the laboratory's monsters were created by combining humans and animals.

Reference: 3DM Guide Team
GAME NOTE has reorganized and rewritten the routes from this walkthrough.